Initial damage to the endothelium results in an inflammatory response. Monocytes enter the artery wall from the bloodstream, with platelets adhering to the area of insult. This may be promoted by redox signaling induction of factors such as VCAM-1 , which recruit circulating monocytes, and M-CSF , which is selectively required for the differentiation of monocytes to macrophages. The monocytes differentiate into macrophages , which proliferate locally,  ingest oxidized LDL, slowly turning into large "foam cells" – so-called because of their changed appearance resulting from the numerous internal cytoplasmic vesicles and resulting high lipid content. Under the microscope, the lesion now appears as a fatty streak. Foam cells eventually die and further propagate the inflammatory process.
I got sucked in by them. Thought it was a real health magazine or something. After I signed up for the Max Shred and Extreme Antler “free trials” I kept looking on the internet for information on them and came here. I immediately called to cancel and because it was right after I ordered them they did void the shipping costs. The lady I spoke with did try to assure me that they do work but I wasn’t having it so she quit trying to feed me that garbage and promptly canceled my order. So at least their customer service was efficient and cordial!
State and local leaders have also made it clear they’re fighting the decision and will continue to fight climate change, with or without federal support. The Climate Mayors Agreement is a commitment between now 8o+ cities including Austin, Palo Alto and San Francisco to ignore Trump’s March executive order that weakened the Clean Power Plan , which would have compelled states to set power plant emissions reductions goals. They want to keep those goals intact. Several of these same cities have jointly signed onto former Mayor Bloomberg’s new plan, which is a coalition of cities, states, and companies who plan on coordinating with the UN directly to come up with carbon emissions targets.