It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.
Testosterone Propionate Many consider propionate to be the mildest testosterone ester, and the preferred form for the dieting/cutting phases of training. Some will go so far as to say that propionate will harden the physique, while giving the user less water and fat retention than one typically expects to see with a testosterone.
During a typical cycle one will see action that is consistent with a testosterone. Users sensitive to gynecomastia and water retention may therefore need to add an anti-estrogen like Arimidex, Femara or Aromasin. Those particularly troubled by gynecomastia may find that a combination of Nolvadex and Proviron works especially well at preventing/halting this occurrence.
In terms of ancillaries, the use of anti-estrogens is advised. For cutting puposes one will want to run Proviron alongside the testosterone for the length of the stack, which will rarely make the use of other anti-estrogens a necessity. If no Proviron or arimidex is used, you may want to keep some Nolvadex handy. Should problems arise starting on 20-40 mg of Nolvadex until a while after problems subside should be sufficient for all intents and purposes. Testosterone, being a heavily aromatizing compound, is also quite suppressive of natural testosterone (most so, safe for nandrolone) so a post-cycle therapy with Nolva/Clomid and HCG is necessary. Usually one will start HCG the last week or two weeks of a stack and run it about 4 weeks. HCG shots of 1500-3000 IU given every 5th or 6th day. That means during the end of a cycle, one shot of HCG is given per two shots of testosterone. A user should also opt to wait on using clomid or Nolvadex until the androgen is cleared. For longer esters that was to 2 weeks, obviously that time-frame should be reduced to 1 week or even half a week for propionate. One will then start on either 40-50 mg of Nolvadex or 150 mg of Clomid per day for a period of two weeks, and then follow it up with 20-25 mg of Nolvadex or 100 mg of Clomid per day for another two weeks. Post-cycle therapy will facilitate the return of natural testosterone and make it more likely for the user to retain most of the mass he gained while on the cycle.